| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin, Vimentin, Slug, Twist, Bax, Bcl-2 |
| Associated microRNA: |
miR-204-5p |
| Biological function: |
Promotes proliferation, migration, invasion and EMT; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by directly binding miR-204-5p and negatively regulating its level; miR-204-5p restoration rescues/abrogates circPVT1 oncogenic effects. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Higher expression of circPVT1 was correlated with poor prognosis of BCa patients; potential diagnostic biomarker and therapeutic target. |
| Description: |
circPVT1 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT and tumor growth, at least partly by acting as a ceRNA that binds and suppresses miR-204-5p, and high circPVT1 is associated with worse overall survival. |
| Confidence score: |
0.6919 |