| Expression pattern: |
UP |
| Associated gene: |
APRIL, Ago2 |
| Associated microRNA: |
miR-578 |
| Biological function: |
promotes proliferation and metastasis; inhibits apoptosis; promotes cell-cycle progression; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-578 to derepress APRIL expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0005785 was related to HCC patients' TNM stage and overall survival; overexpression rendered HCC patients' poor overall survival time |
| Description: |
In hepatocellular carcinoma, hsa_circ_0005785 is up-regulated and promotes malignant phenotypes (proliferation, migration/invasion/metastasis) while inhibiting apoptosis and relieving cell-cycle arrest. Mechanistically, it functions as a cytoplasmic ceRNA sponging miR-578 to derepress the miR-578 target APRIL, thereby driving tumor progression and associating with poor overall survival. |
| Confidence score: |
0.8712 |