| Expression pattern: |
UP |
| Associated gene: |
AGO2, p65 |
| Associated microRNA: |
miR-671 |
| Biological function: |
Promotes CRC cell migration/motility; activates NF-kappaB signaling; induces pro-inflammatory chemokine production and leukocyte (neutrophil) recruitment. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-671, leading to activation of NF-kappaB signaling (p65 phosphorylation/nuclear localization) and enhanced migration; incorporated into AGO2-RISC complex. |
| Biological pathway or process: |
NF-kappaB (promotes); migration (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circGLIS2 is upregulated in colorectal cancer tissues and cell lines and promotes CRC cell migration. Mechanistically, cytoplasmic circGLIS2 functions as a ceRNA by sponging miR-671, thereby activating NF-kappaB signaling (p65 phosphorylation/nuclear localization) and enhancing pro-inflammatory chemokine production with leukocyte recruitment. |
| Confidence score: |
0.8304 |