circRNA basic information
circBase ID: hsa_circ_0006942
Name: hsa_circ_ATP5H
Synonym: circ-ATP5H
Host Gene: ATP5H
Genomic location(hg19): chr17:73038275-73038754:-
Genomic location(hg38): chr17:75042180-75042659:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HBV-associated HCC tissues; adjacent non-tumor tissues
Cell lines:

Huh7; HepG2; HepG2.2.15; Huh7-1.3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TNFAIP3
Associated microRNA: miR-138-5p
Biological function: Promotes HBV DNA replication and decreases/increases viral antigen expression (HBsAg, HBeAg) in HBV-infected HCC cells; knockdown inhibits HBV replication and expression.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-138-5p, thereby up-regulating TNFAIP3 and promoting HBV replication and expression.
Biological pathway or process:

viral replication (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; ELISA
Clinical significance:

Potential biomarker/therapeutic target for HBV-related HCC treatment.
Description:

circ-ATP5H (hsa_circ_0006942) is up-regulated in HBV-positive HCC tissues and HBV-producing HCC cells. Functionally, circ-ATP5H promotes HBV DNA replication and viral antigen (HBsAg/HBeAg) production by sponging miR-138-5p to up-regulate TNFAIP3, forming a circ-ATP5H/miR-138-5p/TNFAIP3 ceRNA axis.
Confidence score:

0.6369
Other information
Title:

Circ-ATP5H Induces Hepatitis B Virus Replication and Expression by Regulating miR-138-5p/TNFAIP3 Axis.

Journal: Cancer management and research
Published: 2020
PubMed ID: 33173336
Study type:

combined biological and clinical study
Data availability: -
Code availability: -