| Expression pattern: |
UP |
| Associated gene: |
JAK1, STAT3 |
| Associated microRNA: |
miR-26a |
| Biological function: |
promotes proliferation and inhibits apoptosis in HCC cells; supports tumorigenesis in vivo |
| Molecular mechanism: |
ceRNA sponge of miR-26a leading to regulation of JAK1 and downstream STAT3 signaling |
| Biological pathway or process: |
JAK/STAT (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; FISH / smFISH; In Vivo Animal Model |
| Clinical significance: |
circ9119 might be important prognostic factors and biological targets for treating HCC; circ9119 high expression associated with larger tumor diameter |
| Description: |
circ9119 is up-regulated in HCC tissues and HCC cell lines and functions as an oncogenic circRNA. It sponges miR-26a to relieve repression of JAK1, thereby promoting JAK1/STAT3 signaling, enhancing proliferation and inhibiting apoptosis; circ9119 silencing suppresses xenograft tumor growth. |
| Confidence score: |
0.6829 |