| Expression pattern: |
UP |
| Associated gene: |
HOXC9 |
| Associated microRNA: |
miR-495 |
| Biological function: |
Promotes NSCLC cell proliferation, migration/invasiveness and tumor growth; acts as a tumor promoter. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-495, thereby relieving miR-495-mediated repression of HOXC9 (post-transcriptional regulation via HOXC9 3'-UTR). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0020123 expression correlates with lymph node invasiveness, TNM stage, tumor size, and low overall survival; may be a prognostic marker in NSCLC. |
| Description: |
hsa_circ_0020123 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC proliferation, migration/invasion and xenograft tumor growth by sponging miR-495 and thereby increasing HOXC9 expression, forming a hsa_circ_0020123/miR-495/HOXC9 axis. High expression associates with worse overall survival, supporting a prognostic/therapeutic relevance. |
| Confidence score: |
0.7628 |