circRNA basic information
circBase ID: hsa_circ_0085494
Name: hsa_circ_TMEM65
Synonym: -
Host Gene: TMEM65
Genomic location(hg19): chr8:125332326-125335616:-
Genomic location(hg38): chr8:124320085-124323375:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: Prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; normal adjacent prostatic tissues
Cell lines:

PC-3; RWPE-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TGFBR3
Associated microRNA: hsa-miR-203, hsa-miR-330-3p, hsa-miR-619, hsa-miR-646, hsa-miR-649, hsa-miR-671-5p, hsa-miR-873, hsa-miR-95
Biological function: unknown
Molecular mechanism: Predicted circRNA-miRNA-mRNA interaction (ceRNA network) involving hsa-miR-330-3p/TGFBR3.
Biological pathway or process:

PI3K/AKT (other); AMPK (other); cell cycle (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; divergent primers PCR; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0085494 is up-regulated in PC-3 prostate cancer cells versus RWPE-1. Bioinformatics predicts a circRNA-miRNA-mRNA axis hsa_circ_0085494/miR-330-3p/TGFBR3, and enrichment suggests involvement of PI3K-Akt and AMPK-related signaling.
Confidence score:

0.3858
Other information
Title:

Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.

Journal: Frontiers in genetics
Published: 2020
PubMed ID: 32922436
Study type:

combined biological and clinical study
Data availability: GSE140927; TCGA
Code availability: -