circRNA basic information
circBase ID: hsa_circ_0078383
Name: hsa_circ_TIAM2
Synonym: -
Host Gene: TIAM2
Genomic location(hg19): chr6:155411422-155448734:+
Genomic location(hg38): chr6:155090288-155127600:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CSCC tissue; para-cancerous cervical tissues; normal cervical tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PP2A/C, KLHL2, ATPBD4, LOC647979, LHX8, ZNF318, SMOC2
Associated microRNA: hsa-miR-520h, hsa-miR-1197, hsa-miR-1298, hsa-miR 520g
Biological function: unknown
Molecular mechanism: Predicted ceRNA mechanism involving hsa-miR-520h and multiple target mRNAs (e.g., PP2A/C, KLHL2, ATPBD4, ZNF318, SMOC2)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

potential diagnostic and therapeutic biomarkers
Description:

hsa_circ_0078383 is down-regulated in CSCC tissues versus normal controls and is incorporated into a predicted circRNA-miRNA-mRNA (ceRNA) network. It is predicted to target miRNAs including hsa-miR-520h with downstream mRNAs such as PP2A/C, KLHL2, ATPBD4, LHX8, ZNF318 and SMOC2.
Confidence score:

0.4032
Other information
Title:

The profile analysis of circular RNAs in cervical cancer.

Journal: Medicine
Published: 2021
PubMed ID: 34596168
Study type:

combined biological and clinical study
Data availability: GSE102686
Code availability: -