| Expression pattern: |
UP |
| Associated gene: |
NOVA2, Ago2 |
| Associated microRNA: |
miR-1182 |
| Biological function: |
Promotes glycolysis, cell viability, migration, invasion, and tumor growth in NSCLC (including hypoxia-induced NSCLC). |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-1182, relieving miR-1182-mediated repression of NOVA2. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000376 expression was related to the poor overall survival of NSCLC patients and may be a potential biomarker for NSCLC treatment. |
| Description: |
circ_0000376 is up-regulated in NSCLC and is further induced by hypoxia. Functionally, it promotes glycolysis and malignant phenotypes (viability, migration, invasion) and supports tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-1182 to increase NOVA2 expression, forming a circ_0000376/miR-1182/NOVA2 axis associated with poor overall survival. |
| Confidence score: |
0.8162 |