| Expression pattern: |
UP |
| Associated gene: |
VEGFA |
| Associated microRNA: |
miR-34a-5p |
| Biological function: |
Promotes glioma cell proliferation, migration and invasion; accelerates glioma progression. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-34a-5p to increase VEGFA expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for screening and diagnosis; potential therapeutic target for glioma. |
| Description: |
circITGA7 is up-regulated in glioma tissues and cell lines and promotes glioma cell proliferation, migration, and invasion. Mechanistically, circITGA7 functions as a ceRNA sponge for miR-34a-5p, thereby increasing VEGFA expression and driving glioma progression. |
| Confidence score: |
0.6479 |