circRNA basic information
circBase ID: hsa_circ_0055467
Name: hsa_circ_POLR1A
Synonym: circ_0055467
Host Gene: POLR1A
Genomic location(hg19): chr2:86274287-86276365:-
Genomic location(hg38): chr2:86047164-86049242:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tumors; adjacent normal tissues
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-330-5p
Biological function: circ_0055467 is upregulated in LUAD tumors, negatively correlates with miR-330-5p, represses miR-330-5p expression, and supports 47 S rRNA levels/Pol I transcription.
Molecular mechanism: circ_0055467 decoys/sponges miR-330-5p, thereby contributing to upregulation of essential PIC components and Pol I transcription/rRNA synthesis in LUAD.
Biological pathway or process:

ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection
Clinical significance:

circ_0055467 is increased in LUAD tumors compared to adjacent normal tissues and inversely correlates with miR-330-5p expression in LUAD tumor samples.
Description:

In LUAD, POLR1A-derived circ_0055467 is upregulated in tumor tissues and inversely correlated with miR-330-5p. The study supports an oncogenic regulatory role in which circ_0055467 decoys/represses miR-330-5p, thereby contributing to enhanced Pol I transcriptional machinery activity and rRNA synthesis.
Confidence score:

0.62
Other information
Title:

MiR-330-5p and miR-1270 target essential components of RNA polymerase I transcription and exhibit a novel tumor suppressor role in lung adenocarcinoma.

Journal: Cancer gene therapy
Published: 2023
PubMed ID: 36253542
Study type:

combined biological and clinical study
Data availability: The data generated in this study are available within the article and its supplementary data files; TCGA gene expression data for LUAD is available from UCSC Xena browser; TCGA Wanderer database
Code availability: -