| Expression pattern: |
UP |
| Associated gene: |
NF-kappaB signal pathway, p65 |
| Associated microRNA: |
miR-125b |
| Biological function: |
CircPVT1 promotes ALL cell proliferation, migration and invasion; circPVT1 knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
CircPVT1 acts as a sponge for miR-125b and promotes ALL progression by modulating the miR-125b/NF-kappaB signal pathway. |
| Biological pathway or process: |
NF-kappaB (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; BrdU; Transwell Assay; Western Blot |
| Clinical significance: |
Circ-PVT1 might be one potential effective target for ALL diagnosis and therapy. |
| Description: |
CircPVT1 is up-regulated in childhood ALL bone marrow samples and ALL cell lines. Functionally, it promotes ALL cell proliferation, migration and invasion, at least partly by adsorbing miR-125b and modulating the NF-kappaB signaling pathway. The study proposes circPVT1 as a potential diagnostic and therapeutic target for ALL. |
| Confidence score: |
0.6521 |