circRNA basic information
circBase ID: hsa_circ_0021593
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33279167-33369559:+
Genomic location(hg38): chr11:33257621-33348013:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissues; adjacent healthy tissues; tumor tissues
Cell lines:

H1975; A549; H1299; HBE1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT, mTOR, HK2, Ki-67, MMP-9, Ago2
Associated microRNA: miR-381-3p
Biological function: promotes proliferation, migration, glycolysis and tumor growth; inhibits apoptosis
Molecular mechanism: circHIPK3 sponges miR-381-3p and activates AKT/mTOR signaling
Biological pathway or process:

proliferation (promotes); migration (promotes); glycolysis (promotes); apoptosis (inhibits); PI3K/AKT/mTOR (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model
Clinical significance:

circHIPK3 expression was closely correlated with tumor size, TNM stage, and lymph node metastasis
Description:

circHIPK3 is up-regulated in lung cancer and functions as an oncogenic circRNA. It promotes proliferation, migration and glycolysis while inhibiting apoptosis by sponging miR-381-3p and activating the AKT/mTOR signaling pathway, and its knockdown suppresses tumor growth in a xenograft model.
Confidence score:

0.7087
Other information
Title:

CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway.

Journal: Open life sciences
Published: 2020
PubMed ID: 33817257
Study type:

combined biological and clinical study
Data availability: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -