circRNA basic information
circBase ID: -
Name: hsa_circ_KIF4A
Synonym: circRNA45436
Host Gene: KIF4A
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

HPV negative normal cervical epithelium; HPV16 positive normal cervical epithelium; HPV16 positive high-grade squamous intraepithelial lesion; HPV16 positive cervical squamous epithelial cell carcinoma tissues; cervical cancer of squamous cell carcinoma t
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: UBE2D2, USP39, PQBP1, ANAPC5, U2AF2, MOV10, ELAVL1, FAM120A, CNBP, UPF1, FMR1, SRSF1, NOP58, SRSF3, NOP56, DDX54, RBM10, HNRNPC, ACIN1, HNRNPA1, FXR1, FXR2, IGF2BP2, IGF2BP3, TARDBP, GTF2F1, RBFOX2, RBM22, AGO2, EIF4A3, FBL
Associated microRNA: hsa-miR-29b-1-5p, hsa-miR-141-5p, hsa-miR-191-3p, hsa-miR-29b-2-5p, hsa-miR-16-1-3p
Biological function: Key DE circRNA involved in cervical cancer progression; forms a validated ceRNA network with hsa-miR-29b-2-5p and UBE2D2; proposed master regulatory network involving survival-associated hub genes.
Molecular mechanism: Validated ceRNA mechanism involving hsa-KIF4A_0022, hsa-miR-29b-2-5p, and UBE2D2; predicted interactions with additional miRNAs and RBPs.
Biological pathway or process:

ceRNA regulation (promotes); lipid metabolism (other); apoptosis (inhibits); p53 signaling (inhibits); cell cycle (other)
Detected method:
Q
S
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential biomarker and therapeutic target; linked to a ceRNA sub-network containing hub genes significantly associated with overall survival in cervical cancer.
Description:

hsa-KIF4A_0022/hsa-KIF4 A_0022 was the key experimentally validated circRNA in this study. It was up-regulated in cervical cancer tissues and formed a positive ceRNA network with hsa-miR-29b-2-5p and UBE2D2, with potential implications for cervical cancer progression, fatty acid/lipid synthesis, and therapeutic targeting.
Confidence score:

0.4032
Other information
Title:

Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.

Journal: Journal of applied genetics
Published: 2025
PubMed ID: 40531429
Study type:

combined biological and clinical study
Data availability: GSE147009; TCGA; CircAtlas; Transcirc; MiRWalk 3.0; CMAP2; CTDBASE
Code availability: -