| Expression pattern: |
UP |
| Associated gene: |
SIX4, PCNA, MCM2, MMP-9, MMP-2, VEGF |
| Associated microRNA: |
miR-384 |
| Biological function: |
hsa-circ-0000670 promotes gastric cancer cell proliferation, migration, invasion, tumor growth, and angiogenesis-related phenotypes; silencing hsa-circ-0000670 inhibits gastric cancer progression in vitro and in vivo. |
| Molecular mechanism: |
hsa-circ-0000670 functions as a competing endogenous RNA by binding miR-384, thereby up-regulating the miR-384 target gene SIX4 and promoting gastric cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
hsa-circ-0000670 was highly expressed in gastric cancer tissues and was proposed as a promising therapeutic target for gastric cancer. |
| Description: |
hsa-circ-0000670 is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer proliferation, migration, invasion, tumor growth, and angiogenesis-related phenotypes by binding miR-384 and up-regulating SIX4, suggesting a potential therapeutic role for targeting hsa-circ-0000670. |
| Confidence score: |
0.8508 |