| Expression pattern: |
DN |
| Associated gene: |
PTEN, PI3K, AKT, p-AKT |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
tumor suppressor; inhibits proliferation; promotes apoptosis; inhibits migration and invasion |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-142-3p and regulates PTEN-PI3K/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
Low expression levels of circRNA_100395 were associated with poor tumor differentiation, advanced Tumor-Node-Metastasis stage, lymph node metastasis and shorter overall survival time. |
| Description: |
circRNA_100395 is down-regulated in gastric cancer tissues/cell lines, and higher circRNA_100395 expression is associated with better overall survival. Functionally, circRNA_100395 overexpression suppresses proliferation, migration and invasion and promotes apoptosis, at least partly by sponging miR-142-3p and inhibiting the PTEN-PI3K/AKT signaling axis. |
| Confidence score: |
0.7126 |