circRNA basic information
circBase ID: -
Name: hsa_circ_OMA1
Synonym: circ_14736
Host Gene: OMA1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm; exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood plasma exosomes
Cell lines:

DU145; PC3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Promotes prostate cancer cell proliferation; higher expression is associated with worse BCR outcome in the prognostic model; detectable in plasma exosomes as a potential liquid biopsy biomarker.
Molecular mechanism: not specified
Biological pathway or process:

proliferation (promotes); immune regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; Bioinformatics Analysis; Cohort Study; Survival Analysis; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Western Blot; Clinical Sample Validation
Clinical significance:

Part of an eight-circRNA risk-score model predicting biochemical recurrence; high expression is associated with worse outcome; detectable in exosomes of PCa patients’ plasma, suggesting potential as a liquid-biopsy marker.
Description:

circ_14736 is included in an eight-circRNA signature predicting biochemical recurrence in prostate cancer, where higher expression indicates worse outcome. Experimentally, circ_14736 shows circular features, is mainly cytoplasmic, promotes proliferation of PCa cells, and can be detected in plasma exosomes from PCa patients.
Confidence score:

0.8209
Other information
Title:

An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.

Journal: Frontiers in cell and developmental biology
Published: 2020
PubMed ID: 33363156
Study type:

combined biological and clinical study
Data availability: GSE113124
Code availability: -