circRNA basic information
circBase ID: hsa_circ_0006117
Name: hsa_circ_PTPRA
Synonym: circ_0006117
Host Gene: PTPRA
Genomic location(hg19): chr20:2944917-2945848:+
Genomic location(hg38): chr20:2964271-2965202:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015486
MONDO name: keratoconus
Disease details: keratoconus
Disease DO ID:
 10126
Disease MeSH ID:
 D007640
Disease NCIt ID:
 C26806
Disease ICD11 ID:
 945228622
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

corneal tissues; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential circulating biomarker for KC diagnosis; blood expression correlates positively with CDVA and negatively with back elevation values of KC eyes.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; ROC Analysis
Clinical significance:

AUC 0.6701 for distinguishing KC patients from healthy controls; expression correlates with CDVA and back elevation values.
Description:

circ_0006117 was down-regulated in KC cornea and peripheral blood. Its blood expression showed diagnostic value and correlated with clinical parameters of KC severity, supporting its role as a circulating biomarker.
Confidence score:

0.4679
Other information
Title:

Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.

Journal: Experimental eye research
Published: 2024
PubMed ID: 38142763
Study type:

combined biological and clinical study
Data availability: Available from the corresponding author on reasonable request; Data will be made available on request; Supplementary data can be found online at https://doi. org/10.1016/j.exer.2023.109759.
Code availability: -