| Expression pattern: |
UP |
| Associated gene: |
CDK6 |
| Associated microRNA: |
miR-147a |
| Biological function: |
promotes EOC cell proliferation and migration/invasion; inhibits apoptosis; enhances tumorigenesis/tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-147a to relieve repression of CDK6, thereby increasing CDK6 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; TUNEL; In Vivo Animal Model |
| Clinical significance: |
Expression of circ_0072995 was positively correlated with pathological grades in EOC patients |
| Description: |
circ_0072995 is up-regulated in epithelial ovarian cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes EOC proliferation, migration/invasion and tumor growth while suppressing apoptosis, by sponging miR-147a to derepress CDK6 (circ_0072995/miR-147a/CDK6 axis). Its expression correlates with pathological grade in EOC patients. |
| Confidence score: |
0.6837 |