circRNA basic information
circBase ID: -
Name: hsa_circ_NUP98
Synonym: circNUP98
Host Gene: NUP98
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

GBM tissue; paired non-cancer tissues
Cell lines:

U87; U-251
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: miR-519a-3p
Biological function: promotes GBM cell proliferation and tumor growth
Molecular mechanism: circNUP98 interacts with pre-mature miR-519a-3p and suppresses its maturation, reducing mature miR-519a-3p and increasing STAT3 expression
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; BrdU; CCK8; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circNUP98 is up-regulated in glioblastoma/GBM. It binds pre-mature miR-519a-3p and suppresses its maturation, leading to reduced mature miR-519a-3p, increased STAT3 mRNA, enhanced GBM cell proliferation, and increased tumor growth in an intracranial U87 xenograft model.
Confidence score:

0.7718
Other information
Title:

CircNUP98 Suppresses the Maturation of miR-519a-3p in Glioblastoma.

Journal: Frontiers in neurology
Published: 2021
PubMed ID: 34867700
Study type:

combined biological and clinical study
Data availability: -
Code availability: -