circRNA basic information
circBase ID: hsa_circ_0000140
Name: hsa_circ_KIAA0907
Synonym: circ_0000140
Host Gene: KIAA0907
Genomic location(hg19): chr1:155891165-155895634:-
Genomic location(hg38): chr1:155921374-155925843:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; non-tumor margin tissues; tumor tissues
Cell lines:

CAL-27; SCC-4; SCC-9; SCC-25; HOK
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: CDC73
Associated microRNA: miR-182-5p
Biological function: Suppresses proliferation, migration, invasion/metastasis and glycolysis metabolism in OSCC; inhibits tumor growth in vivo.
Molecular mechanism: Acts as a miRNA sponge for miR-182-5p to upregulate CDC73.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); metastasis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model
Clinical significance:

Lower circ_0000140 expression is associated with lymph node metastasis in OSCC.
Description:

circ_0000140 is down-regulated in OSCC tissues and cell lines and is mainly localized in the cytoplasm. Its overexpression suppresses OSCC cell proliferation, migration/invasion and glycolysis, and inhibits tumor growth in a xenograft model, at least partly via the circ_0000140/miR-182-5p/CDC73 axis.
Confidence score:

0.6996
Other information
Title:

Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32863766
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -