circRNA basic information
circBase ID: -
Name: hsa_circ_ANRIL
Synonym: circANRIL e7-e5
Host Gene: ANRIL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004992
MONDO name: cancer
Disease details: oncogene-induced senescence
Disease DO ID:
 0050686, 0050687, 162
Disease MeSH ID:
 -
Disease NCIt ID:
 C9305
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

WI38 hTERT RAF1-ER; IMR90 hTERT deltaMEK1-ER; BJ hTERT BRAF V600E
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: In proliferative cells represses p15 expression; in RAF1-induced senescence supports full induction of INK4 genes (p15, p16, p14ARF).
Molecular mechanism: Acts in transcriptional regulation of INK4 locus; functional switch proposed depending on Polycomb vs circular ANRIL ratio.
Biological pathway or process:

cell cycle (other); proliferation (other); ceRNA regulation (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Transfection; RNA-seq; Bioinformatics Analysis; Luciferase Reporter Assay
Clinical significance:

-
Description:

circANRIL e7-e5 is induced in RAF1-driven oncogene-induced senescence and, together with circANRIL e16-e5, is required for full transcriptional induction of INK4 locus genes (p15, p16, p14ARF) in senescent cells, while repressing p15 in proliferative fibroblasts.
Confidence score:

0.6715
Other information
Title:

Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence.

Journal: RNA biology
Published: 2021
PubMed ID: 32862732
Study type:

biological research
Data availability: GSE 143957
Code availability: -