circRNA basic information
circBase ID: hsa_circ_0027353
Name: -
Synonym: chr12:62715245-62749256+
Host Gene: -
Genomic location(hg19): chr12:62715244-62749256:+
Genomic location(hg38): chr12:62321463-62355475:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015540
MONDO name: hemophagocytic syndrome
Disease details: NK/T-cell lymphoma-associated hemophagocytic syndrome
Disease DO ID:
 0050120
Disease MeSH ID:
 -
Disease NCIt ID:
 C34792
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-29b-1-5p, hsa-miR-6843-3p, hsa-miR-7-5p, hsa-miR-1299, hsa-miR-6876-3p
Biological function: Potential diagnostic biomarker of early NK/T-LAHS
Molecular mechanism: Predicted miRNA sponge (ceRNA) based on miRNA binding site predictions
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May be potential biomarkers for NK/T-LAHS
Description:

hsa_circ_0027353 is up-regulated in NK/T-LAHS serum and validated by RT-qPCR consistent with RNA-seq. It was selected due to predicted NK/T-LAHS-related miRNA binding sites, supporting a potential miRNA-sponge/ceRNA role and diagnostic biomarker potential.
Confidence score:

0.4032
Other information
Title:

Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.

Journal: Bioscience reports
Published: 2020
PubMed ID: 32856037
Study type:

combined biological and clinical study
Data availability: -
Code availability: -