circRNA basic information
circBase ID: hsa_circ_0073586
Name: -
Synonym: chr5:112090570-112137080+
Host Gene: -
Genomic location(hg19): chr5:112090569-112137080:+
Genomic location(hg38): chr5:112754872-112801383:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015540
MONDO name: hemophagocytic syndrome
Disease details: NK/T-cell lymphoma-associated hemophagocytic syndrome
Disease DO ID:
 0050120
Disease MeSH ID:
 -
Disease NCIt ID:
 C34792
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-6821-3p, hsa-miR-6728-3p, hsa-miR-6800-3p, hsa-miR-337-5p, hsa-miR-7-5p
Biological function: Potential diagnostic biomarker of early NK/T-LAHS
Molecular mechanism: Predicted miRNA sponge (ceRNA) based on miRNA binding site predictions
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May serve as a valuable diagnostic biomarker of early NK/T-LAHS
Description:

hsa_circ_0073586 is significantly up-regulated in NK/T-LAHS patient serum (NGS and RT-qPCR consistent). It was selected based on predicted NK/T-LAHS-related miRNA binding sites, suggesting a potential ceRNA/miRNA-sponge role and potential diagnostic biomarker value.
Confidence score:

0.4032
Other information
Title:

Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.

Journal: Bioscience reports
Published: 2020
PubMed ID: 32856037
Study type:

combined biological and clinical study
Data availability: -
Code availability: -