circRNA basic information
circBase ID: hsa_circ_0001998
Name: hsa_circ_FUT8
Synonym: -
Host Gene: FUT8
Genomic location(hg19): chr14:65922338-66028484:+
Genomic location(hg38): chr14:65455620-65561766:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor tissues; adjacent normal samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HNRNPC
Associated microRNA: miR-185-5p
Biological function: Predicted as an upregulated FUT8-linked circRNA potentially involved in NSCLC development through the circFUT8/miR-185-5p/HNRNPC ceRNA network.
Molecular mechanism: Bioinformatically predicted ceRNA mechanism involving miR-185-5p and HNRNPC.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001998 was identified by bioinformatics analysis as an upregulated FUT8-linked circRNA in NSCLC datasets and as a predicted upstream regulator of miR-185-5p in the HNRNPC-centered ceRNA network. The paper does not report separate RT-qPCR or functional validation specifically for hsa_circ_0001998.
Confidence score:

0.1768
Other information
Title:

Epigenetic modulation of cisplatin sensitivity by the M6A-linked ceRNA network in non-small cell lung cancer.

Journal: American journal of physiology. Cell physiology
Published: 2025
PubMed ID: 40293839
Study type:

bioinformatics study
Data availability: GSE101586; GSE101684; GSE112214; https://doi.org/10.6084/m9.figshare.28407431
Code availability: -