circRNA basic information
circBase ID: hsa_circ_0001955
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr15:64495280-64508912:-
Genomic location(hg38): chr15:64203081-64216713:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor samples; adjacent normal tissue samples
Cell lines:

Huh-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ESRP2
Associated microRNA: -
Biological function: -
Molecular mechanism: ESRP2 may inhibit circRNA biogenesis/expression (splicing regulation).
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection
Clinical significance:

-
Description:

hsa_circ_0001955 is up-regulated in HCC and its expression increases upon ESRP2 knockdown in Huh-7 cells, supporting a model where the RBP ESRP2 represses its biogenesis/expression via splicing regulation.
Confidence score:

0.3213
Other information
Title:

Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.

Journal: International journal of molecular sciences
Published: 2021
PubMed ID: 34299096
Study type:

bioinformatics study
Data availability: GSE94508; GSE97332; TCGA-LIHC; ENCSR519QAA; ENCSR872EVQ; ENCSR945NSF; ENCSR624GNZ; ENCSR476BQA; ENCSR828ZID; ENCSR256CHX; ENCSR339FUY; ENCSR773KRC; ENCSR989VIY; ENCSR973HOJ; ENCSR489ABS; ENCSR861PAR
Code availability: -