| Expression pattern: |
DN |
| Associated gene: |
AIF1L, Ago2, GLIS3 |
| Associated microRNA: |
miR-146b-3p |
| Biological function: |
circGLIS3 functions as a tumor suppressor that inhibits thyroid cancer cell migration, invasion and metastasis, attenuates EMT, and is negatively associated with malignant clinical features including capsular invasion and lymph node metastasis. |
| Molecular mechanism: |
circGLIS3 acts as a cytoplasmic ceRNA/miRNA sponge for miR-146b-3p, thereby upregulating AIF1L and inhibiting thyroid cancer migration and invasion through the miR-146b-3p/AIF1L axis. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
Low expression of circGLIS3 in PTC tissues was significantly associated with capsule invasion and lymph node metastasis; circGLIS3 has potential as a promising diagnostic and prognostic marker for thyroid cancer. |
| Description: |
circGLIS3/hsa_circ_0007368 is a GLIS3-derived human circRNA that is down-regulated in papillary thyroid carcinoma tissues and thyroid cancer cell lines. It suppresses thyroid cancer migration, invasion, EMT and lung metastasis by sponging miR-146b-3p and increasing AIF1L expression. Low circGLIS3 expression is associated with capsular invasion and lymph node metastasis, suggesting diagnostic or prognostic potential. |
| Confidence score: |
0.8571 |