| Expression pattern: |
UP |
| Associated gene: |
SOX4, Wnt/beta-catenin pathway |
| Associated microRNA: |
miR-17-5p |
| Biological function: |
Promotes apoptosis, inhibits proliferation, and promotes extracellular matrix (ECM) degradation in nucleus pulposus (NP) cells during IDD progression. |
| Molecular mechanism: |
Acts as a miR-17-5p sponge to de-repress SOX4 and activate Wnt/beta-catenin signaling, thereby promoting ECM degradation. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); apoptosis (promotes); proliferation (inhibits); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
circITCH is up-regulated in IDD nucleus pulposus tissues and promotes NP-cell apoptosis, suppresses proliferation, and accelerates ECM degradation. Mechanistically, circITCH sponges miR-17-5p to increase SOX4 and activate Wnt/beta-catenin signaling, driving degenerative changes. |
| Confidence score: |
0.6479 |