circRNA basic information
circBase ID: hsa_circ_0039943
Name: hsa_circ_SLC7A6
Synonym: CircSLC7A6
Host Gene: SLC7A6
Genomic location(hg19): chr16:68300495-68300624:+
Genomic location(hg38): chr16:68266592-68266721:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

RWPE-1; 22RV1; PC3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-143
Biological function: may promote bone metastasis
Molecular mechanism: predicted miRNA sponge interaction with miR-143
Biological pathway or process:

metastasis (other); EMT (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

In prostate cancer cell line models, CircSLC7A6 (hsa_circ_0039943) is up-regulated in PC3 vs 22RV1 and is predicted (bioinformatically) to bind miR-143, suggesting a potential ceRNA role related to PCa progression/bone metastasis.
Confidence score:

0.4276
Other information
Title:

Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.

Journal: Future science OA
Published: 2018
PubMed ID: 30416748
Study type:

biological research
Data availability: -
Code availability: -