| Expression pattern: |
UP |
| Associated gene: |
UBE2Q1, FOXA1, Ago2 |
| Associated microRNA: |
miR-1179 |
| Biological function: |
Promotes cervical cancer cell proliferation and migration and inhibits apoptosis. |
| Molecular mechanism: |
FOXA1 transcriptionally activates the host gene OSBPL10 to induce circOSBPL10; circOSBPL10 acts as a miRNA sponge for miR-1179 to upregulate UBE2Q1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; TUNEL; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; ChIP / ChIP-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circOSBPL10 (hsa_circ_0064669), derived from OSBPL10, is up-regulated in cervical cancer cell lines and mainly localized in the cytoplasm. It promotes proliferation and migration (and suppresses apoptosis) by acting as a ceRNA that sponges miR-1179, thereby increasing UBE2Q1 expression; FOXA1 transcriptionally activates OSBPL10 to induce circOSBPL10. |
| Confidence score: |
0.808 |