circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA7
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SKhep1; HA22T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: VE‐cadherin, Notch4, AR
Associated microRNA: miR-7-5p
Biological function: Suppresses vasculogenic mimicry formation in HCC (as part of the AR-mediated pathway).
Molecular mechanism: AR suppresses circRNA7 transcription by targeting its host gene promoter; circRNA7 modulates miR-7-5p, which directly targets VE-cadherin and Notch4 3′UTRs, affecting VM formation.
Biological pathway or process:

ceRNA regulation (other); angiogenesis (inhibits); metastasis (inhibits); invasion (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; ChIP / ChIP-seq; Transfection
Clinical significance:

-
Description:

In HCC cells, AR suppresses circRNA7 expression by binding the circRNA7 host gene promoter. Reduced circRNA7 increases miR-7-5p activity, which represses VE-cadherin and Notch4, thereby inhibiting vasculogenic mimicry formation.
Confidence score:

0.4844
Other information
Title:

Androgen receptor suppresses vasculogenic mimicry in hepatocellular carcinoma via circRNA7/miRNA7-5p/VE-cadherin/Notch4 signalling.

Journal: Journal of cellular and molecular medicine
Published: 2020
PubMed ID: 33118329
Study type:

biological research
Data availability: All data generated or analysed during this study are available from the corresponding author upon request.
Code availability: -