| Expression pattern: |
UP |
| Associated gene: |
RUNX1 |
| Associated microRNA: |
miR-296-5p |
| Biological function: |
promotes cell proliferation and cell cycle progression and inhibits apoptosis in colorectal cancer; circ_0000512 knockdown suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0000512 sponges miR-296-5p to upregulate RUNX1 |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000512 expression is associated with poor survival in CRC patients |
| Description: |
circ_0000512 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. Its knockdown inhibits proliferation, induces G0/G1 arrest and promotes apoptosis by functioning as a miR-296-5p sponge to increase RUNX1 expression, and it suppresses xenograft tumor growth in vivo. |
| Confidence score: |
0.8399 |