| Expression pattern: |
UP |
| Associated gene: |
CXCL13, AGO2 |
| Associated microRNA: |
miR-508-3p |
| Biological function: |
promotes ccRCC cell proliferation, migration, invasion and metastasis |
| Molecular mechanism: |
circHIPK3 functions as a miRNA sponge/decoy for miR-508-3p to increase CXCL13 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; ISH (In Situ Hybridization); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circHIPK3 expression was associated with poor clinicopathological features, shorter overall survival, and had diagnostic value (ROC AUC 0.95322) in ccRCC |
| Description: |
circHIPK3 is upregulated in ccRCC and promotes proliferation and metastatic behaviors. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-508-3p, thereby relieving repression of CXCL13 and enhancing CXCL13 expression. High circHIPK3 is associated with worse clinicopathological features and poorer overall survival. |
| Confidence score: |
0.8659 |