| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with relapse, worse survival, and bortezomib resistance in multiple myeloma (biomarker role). |
| Molecular mechanism: |
Not investigated in this study (no functional/mechanistic experiments). |
| Biological pathway or process: |
drug resistance (other); not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Survival Analysis |
| Clinical significance: |
High exosomal circMYC is an independent predictor of poor prognosis and is associated with higher relapse and mortality; potential diagnostic/prognostic biomarker for MM. |
| Description: |
Circulating serum exosomal circMYC (hsa_circ_0085533, host gene MYC) is up-regulated in multiple myeloma and is higher in bortezomib-resistant/relapsed settings. High exosomal circMYC predicts higher relapse and mortality and independently indicates poor OS/PFS, supporting its use as a diagnostic/prognostic biomarker; mechanistic functions were not tested. |
| Confidence score: |
0.5727 |