circRNA basic information
circBase ID: hsa_circ_0000497
Name: hsa_circ_SLAIN1
Synonym: -
Host Gene: SLAIN1
Genomic location(hg19): chr13:78293666-78327493:+
Genomic location(hg38): chr13:77719531-77753358:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson's disease
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FUS, TDP43, FMR1, ATXN2
Associated microRNA: miR-516b-5p, miR-526b-5p, miR-578, miR-659-3p, miR-1197, miR-526b, miR-659
Biological function: unknown
Molecular mechanism: Predicted miRNA and RBP sponging by SLAIN1_circ_0000497 in PD; in silico circRNA-miRNA and circRNA-RBP networks were constructed.
Biological pathway or process:

ceRNA regulation (other); MAPK (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Included in a 4-circRNA panel distinguishing iPD from healthy controls with AUC 0.84.
Description:

SLAIN1_circ_0000497 is down-regulated in PBMCs of idiopathic PD patients and is part of a 4-circRNA diagnostic classifier. It is predicted to act through miRNA/RBP sequestration within PD-related regulatory networks.
Confidence score:

0.459
Other information
Title:

Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.

Journal: Movement disorders : official journal of the Movement Disorder Society
Published: 2021
PubMed ID: 33433033
Study type:

combined biological and clinical study
Data availability: The datasets analyzed during this study are all available from the corresponding author on request.
Code availability: -