| Expression pattern: |
DN |
| Associated gene: |
PTEN, AKT, TRAF6, IGF-1, Ago2 |
| Associated microRNA: |
miR-4470 |
| Biological function: |
suppresses CRC cell proliferation, migration, invasion and EMT, and promotes apoptosis; suppresses tumor growth and lung metastasis in vivo |
| Molecular mechanism: |
ceRNA sponging miR-4470 to elevate PTEN; competitively binds TRAF6 (Ring finger domain) to inhibit K63-linked AKT ubiquitination and reduce AKT phosphorylation (Thr-308/Ser-473), thereby regulating PTEN/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); ubiquitination (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; FISH / smFISH; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; TUNEL; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Co-IP; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
low expression of circPTEN was closely correlated to poor prognosis; circPTEN expression was lower in CRC patients at advanced stages (III to IV) and markedly downregulated in metastatic CRC tissues |
| Description: |
circPTEN (hsa_circ_0094343) is down-regulated in colorectal cancer and acts as a tumor suppressor. It increases PTEN expression by sponging miR-4470 and also binds TRAF6 to inhibit K63-linked AKT ubiquitination and AKT phosphorylation, thereby suppressing PTEN/AKT signaling, EMT, proliferation, invasion and metastasis while promoting apoptosis. Low circPTEN expression is associated with poor prognosis. |
| Confidence score: |
0.8862 |