| Expression pattern: |
DN |
| Associated gene: |
PTPRG, Ago2 |
| Associated microRNA: |
miR-567 |
| Biological function: |
inhibits LUAD growth and metastasis; suppresses proliferation, migration and invasion |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: cMras sponges miR-567 to release/upregulate PTPRG |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
cMras expression was negatively associated with tumour stages; suggested as a potential biomarker |
| Description: |
cMras is down-regulated in LUAD and functions as a tumor suppressor by inhibiting proliferation, migration, invasion and in vivo metastasis. Mechanistically, it acts as a miR-567 sponge to de-repress PTPRG, forming a cMras/miR-567/PTPRG regulatory axis. |
| Confidence score: |
0.8532 |