circRNA basic information
circBase ID: hsa_circ_0034616
Name: hsa_circ_RAD51
Synonym: -
Host Gene: RAD51
Genomic location(hg19): chr15:41001222-41021022:+
Genomic location(hg38): chr15:40709024-40728824:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MG63
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-18a-5p
Biological function: associated with proliferation- and apoptosis-related processes during 5-FU treatment
Molecular mechanism: predicted circRNA-miRNA-mRNA interaction network (ceRNA-like)
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0034616 is up-regulated in 5-FU-treated MG63 osteosarcoma cells and was included in predicted circRNA-miRNA-mRNA networks related to proliferation/apoptosis. It was predicted to target miR-18a-5p, suggesting a ceRNA-like role during 5-FU response.
Confidence score:

0.4761
Other information
Title:

The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.

Journal: Technology in cancer research & treatment
Published: 2020
PubMed ID: 33308021
Study type:

biological research
Data availability: Supplemental material for this article is available online; Table S1; Table S2
Code availability: -