| Expression pattern: |
UP |
| Associated gene: |
AKT3, E2F7 |
| Associated microRNA: |
miR-545 |
| Biological function: |
inhibits apoptosis; promotes invasion; promotes proliferation |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-545 to regulate AKT3 protein expression; involves E2F7 as a downstream target gene associated with prognosis. |
| Biological pathway or process: |
apoptosis (inhibits); invasion (promotes); proliferation (promotes); PI3K/AKT (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; FISH / smFISH; Transfection; Western Blot; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-PRKCI distribution increased with depth of invasion, lymph node metastasis, distant metastasis, and TNM stage; may affect survival and prognosis of HCC patients. |
| Description: |
circ-PRKCI is up-regulated in HCC tissues and HCC cell lines. It promotes malignant phenotypes (invasion and proliferation) and inhibits apoptosis, at least partly by acting as a miR-545 sponge to modulate AKT3 protein, with downstream association to E2F7-related prognosis. |
| Confidence score: |
0.7357 |