circRNA basic information
circBase ID: hsa_circ_0067717
Name: hsa_circ_RNF13
Synonym: circRNA_0067717
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CNE-1 (CVCL_6888), HNE-2 (CVCL_FA07) cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: TRIM41, p53
Associated microRNA: -
Biological function: circRNA_0067717 promoted paclitaxel chemoresistance of NPC in vitro and in vivo
Molecular mechanism: circRNA_0067717/TRIM41/p53 axis
Survival: -
Supported No.:
 2
Description:

We demonstrate that circRNA_0067717 acts as a scaffold for TRIM41 and p53, enhancing paclitaxel chemoresistance in NPC by promoting TRIM41-induced p53 degradation via ubiquitination.
Other information
Title:

circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53.

Journal: Cell Oncol (Dordr)
Published: 2023/1/28
PubMed ID: 36705889