circRNA basic information
circBase ID: hsa_circ_0128298
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paratumorous tissues; liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: may promote proliferation and metastasis
Molecular mechanism: -
Biological pathway or process:

proliferation (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

Diagnostic biomarker (ROC AUC =0.668) and prognostic factor; high hsa_circ_0128298 expression predicts poor survival (OS).
Description:

hsa_circ_0128298 is significantly up-regulated in hepatocellular carcinoma tissues versus paratumorous tissues. Higher expression is associated with metastasis-related clinicopathological features and predicts worse overall survival, and it shows moderate diagnostic value by ROC analysis.
Confidence score:

0.5416
Other information
Title:

Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma.

Journal: Cancer management and research
Published: 2018
PubMed ID: 29849467
Study type:

combined biological and clinical study
Data availability: -
Code availability: -