circRNA basic information
circBase ID: hsa_circ_0000523
Name: -
Synonym: circ_006229
Host Gene: -
Genomic location(hg19): chr14:21971315-21972024:-
Genomic location(hg38): chr14:21503172-21503881:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Caco-2; COLO205; COLO320HSR; DLD-1; HCT-15; HT-29; SW480; SW620; LoVo; HCT-8; LS 174T; SW1116; FHC; NCM460; HEK293A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Dkk1, beta-Catenin, c-Myc
Associated microRNA: miR-31
Biological function: Inhibits colorectal cancer cell proliferation and induces apoptosis.
Molecular mechanism: Acts as a miR-31 sponge; via miR-31 affects Dkk1 and activates/suppresses Wnt/beta-catenin signaling.
Biological pathway or process:

Wnt/beta-catenin (inhibits); proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

hsa_circ_0000523 is down-regulated in colorectal cancer cell lines and functions as a tumor-suppressive circRNA by inhibiting proliferation and promoting apoptosis. Mechanistically, it sponges miR-31 and thereby suppresses Wnt/beta-catenin signaling (with effects on Dkk1, nuclear beta-catenin and c-Myc).
Confidence score:

0.5223
Other information
Title:

Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Published: 2018
PubMed ID: 30403259
Study type:

biological research
Data availability: -
Code availability: -