| Expression pattern: |
UP |
| Associated gene: |
RAP2C |
| Associated microRNA: |
miR-324-3p |
| Biological function: |
Promotes HCC cell viability/proliferation, migration and invasion; inhibits apoptosis; promotes tumorigenesis in vivo. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-324-3p to relieve repression of RAP2C, increasing RAP2C expression; validated by luciferase and rescue assays (miR-324-3p inhibitor or RAP2C overexpression). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
High circZNF609 expression was associated with shorter overall survival and poorer clinical outcomes. |
| Description: |
circZNF609 is upregulated in hepatocellular carcinoma and is associated with poor clinical outcomes. Functionally, it promotes HCC cell proliferation/viability, migration and invasion while suppressing apoptosis, and it enhances tumor growth in a HepG2 xenograft model. Mechanistically, it acts as a ceRNA sponge for miR-324-3p to increase RAP2C expression. |
| Confidence score: |
0.7829 |