circRNA basic information
circBase ID: hsa_circ_0000199
Name: hsa_circ_AKT3
Synonym: circ_0000199
Host Gene: AKT3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

SCC4; SCC9; SCC25; HN12; CAL27; HOK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CPEB3, PAN2, RLIM, NEXMIF, CFL2, PHACTR2
Associated microRNA: miR-145-5p, miR-29b-3p
Biological function: promotes proliferation; inhibits apoptosis
Molecular mechanism: Bioinformatics-predicted ceRNA/miRNA sponge: circ_0000199 binds miR-145-5p and miR-29b-3p, associated with increased expression of their target genes (e.g., CPEB3, PAN2, RLIM, CFL2) and enrichment of ECM-receptor interaction and TGF-beta signaling pathways.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); TGF-beta/SMAD (other); MAPK (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; TUNEL
Clinical significance:

High exosomal circ_0000199 is associated with lower overall survival and disease-free survival, and is an independent prognostic factor for OSCC.
Description:

circ_0000199 is up-regulated in circulating (serum) exosomes of OSCC patients and its high level predicts worse OS and DFS and higher recurrence/mortality. Functionally, circ_0000199 promotes OSCC cell proliferation and inhibits apoptosis, and is predicted to sponge miR-145-5p/miR-29b-3p to affect downstream targets (e.g., CPEB3, PAN2, RLIM, CFL2) and pathways including ECM-receptor interaction and TGF-beta signaling.
Confidence score:

0.6304
Other information
Title:

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC.

Journal: Scientific reports
Published: 2020
PubMed ID: 32792549
Study type:

combined biological and clinical study
Data availability: All data generated or analysed during this study are included in this published article.
Code availability: -