| Expression pattern: |
DN |
| Associated gene: |
TRIM62, Ago2 |
| Associated microRNA: |
miR-1180-3p |
| Biological function: |
Suppresses LUAD cell proliferation, migration, invasion, and Warburg effect under hypoxia; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-1180-3p to increase TRIM62 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Downregulation of circ_0008193 was correlated with tumor size and lymph node metastasis, and circ_0008193 expression level was associated with overall survival of LUAD patients. |
| Description: |
hsa_circ_0008193 (circ_0008193), derived from FAM120A, is down-regulated in LUAD tissues and cell lines, further decreased under hypoxia. Its overexpression suppresses proliferation, migration/invasion, and glycolysis (Warburg effect) in hypoxic LUAD cells and inhibits xenograft growth by sponging miR-1180-3p to upregulate TRIM62. |
| Confidence score: |
0.7843 |