| Expression pattern: |
UP |
| Associated gene: |
STAT3 |
| Associated microRNA: |
miR-637 |
| Biological function: |
promotes OS cell proliferation, migration, invasion, and growth |
| Molecular mechanism: |
Acts as a sponge for miR-637 to increase STAT3 expression (ceRNA axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
may be a prognostic marker and a promising therapeutic target for OS |
| Description: |
circHIPK3 is up-regulated in osteosarcoma tissues and cell lines and promotes osteosarcoma cell proliferation, migration, and invasion. Mechanistically, it mainly localizes in the cytoplasm and functions as a miR-637 sponge to de-repress STAT3, forming a circHIPK3/miR-637/STAT3 regulatory axis with potential prognostic/therapeutic relevance. |
| Confidence score: |
0.6676 |