| Expression pattern: |
UP |
| Associated gene: |
SMAD6, Ago2 |
| Associated microRNA: |
miR-326 |
| Biological function: |
promotes cell proliferation, colony formation, migration and invasion; promotes cell cycle progression; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) sponging miR-326 to regulate SMAD6 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High hsa_circ_0000517 expression was associated with shorter survival time in HCC patients and correlated with tumor size, TNM state, and lymph node metastasis |
| Description: |
In hepatocellular carcinoma, hsa_circ_0000517 is up-regulated and functions as an oncogenic circRNA by promoting proliferation, cell-cycle progression, migration/invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-326 to increase SMAD6, forming a hsa_circ_0000517/miR-326/SMAD6 regulatory axis associated with poor patient survival. |
| Confidence score: |
0.8006 |