circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: CDR1as
Host Gene: CDR1
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

RWPE-1; PC3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KLF4, RAF1, PAK1, IRS2, IRS1, AKT, ACK1, FAK, IGF1R, HNF4, SNCA, mTOR, NOTCH1, PIK3CD
Associated microRNA: miR-7
Biological function: may substantially contribute to bone metastatic progress of PCa
Molecular mechanism: miRNA sponge of miR-7 with many binding sites
Biological pathway or process:

metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

CDR1as (hsa_circ_0001946) is highly up-regulated in PC3 cells and is proposed to contribute to bone metastatic progression of prostate cancer, consistent with a miR-7 sponge mechanism.
Confidence score:

0.4276
Other information
Title:

Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.

Journal: Future science OA
Published: 2018
PubMed ID: 30416748
Study type:

biological research
Data availability: -
Code availability: -