| Expression pattern: |
UP |
| Associated gene: |
GNB1 |
| Associated microRNA: |
miR-326 |
| Biological function: |
promotes proliferation, migration, invasion and metastasis of cervical cancer cells |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-326, thereby relieving repression of GNB1 and regulating ERK signaling. |
| Biological pathway or process: |
ERK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; FISH / smFISH; ISH (In Situ Hybridization); Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis |
| Clinical significance: |
High circ_POLA2 expression predicts worse overall survival (OS) and disease-free survival (DFS) in CESC patients. |
| Description: |
circ_POLA2 is up-regulated in CESC and associated with poor prognosis. It promotes cervical cancer proliferation, migration/invasion and metastasis by acting as a ceRNA that sponges miR-326, leading to increased GNB1 and activation of ERK signaling. |
| Confidence score: |
0.8427 |