| Expression pattern: |
UP |
| Associated gene: |
E2F7, RIG-1, Ago2 |
| Associated microRNA: |
miR-545 |
| Biological function: |
Promotes glioma cell growth/survival/proliferation/migration and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA-like) for miR-545, affecting miR-545 targets (E2F7 and RIG-1); association supported by Ago2-RIP and genetic epistasis with miR-545 inhibition/KO. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circPRKCI is up-regulated in human glioma tissues and glioma cells and functions as an oncogenic circRNA. It promotes glioma cell proliferation/survival and migration and suppresses apoptosis, mainly by sponging miR-545 and thereby modulating miR-545 targets such as E2F7 and RIG-1; circPRKCI knockdown suppresses A172 xenograft growth in mice. |
| Confidence score: |
0.6833 |