circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: -
Host Gene: NRIP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes; CRC tissues; adjacent normal tissues (ANTs); cell cultured media
Cell lines:

FHC; HCT-116; SW-480
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serves as a circulating exosomal diagnostic biomarker for colorectal cancer; tumor-derived elevated exosomal level in CRC patient serum.
Molecular mechanism: Not investigated (diagnostic biomarker study); origin analysis suggests tumor-derived exosomal release.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis; RNA-seq
Clinical significance:

Circulating exosomal hsa-circ-0004771 is significantly up-regulated in CRC patient sera and shows diagnostic efficacy by ROC analysis; expression correlates with TNM stage and distant metastasis.
Description:

This study identifies circulating serum exosomal hsa-circ-0004771 (circNRIP1) as up-regulated in colorectal cancer and evaluates it as a diagnostic biomarker using qRT-PCR and ROC analysis. Postoperative decrease and exosome-inhibition experiments support that its elevated serum exosomal level is tumor-derived, while its biological mechanism in CRC was not resolved.
Confidence score:

0.5047
Other information
Title:

Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer.

Journal: Frontiers in genetics
Published: 2019
PubMed ID: 31737058
Study type:

combined biological and clinical study
Data availability: GSE100206; GSE100063
Code availability: -