| Expression pattern: |
UN |
| Associated gene: |
APAF1, Ago2 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
enhances cisplatin chemosensitivity and induces apoptosis in bladder cancer cells |
| Molecular mechanism: |
Cdr1as sponges miR-1270 to abolish its repression of APAF1, thereby upregulating APAF1 and promoting apoptosis/chemosensitivity |
| Biological pathway or process: |
apoptosis (promotes); drug resistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Cdr1as is potentially playing role in predicting and monitoring cisplatin chemosensitivity in patients with bladder cancer. |
| Description: |
In bladder cancer, Cdr1as increases cisplatin chemosensitivity by promoting apoptosis. Mechanistically, Cdr1as acts as a ceRNA that sponges miR-1270, relieving repression of APAF1 and increasing APAF1 expression. |
| Confidence score: |
0.7778 |